Endocrine Abstracts

Background: Hemangiomas of the thyroid gland are extremely rare.Case presentation: We report a case of a 78-year-old euthyroid male patient with a primary cavernous hemangioma of the thyroid gland. The patient presented for evaluation of a symptomatic, slowly growing neck mass. He did not have any previous medical history and, moreover, had no history of trauma, FNA or other neck procedures. Ultrasound scan revealed a multinodular goiter and a hypoechoic...

Medullary thyroid carcinoma is an uncommon malignancy of hereditary and sporadic presentation. Mutations in the RET-protooncogene are involved in the pathogenesis of >50% of the sporadic cases. Currently, there is no effective treatment for metastatic medullary thyroid carcinoma. The aim was to present a case of metastatic medullary thyroid carcinoma that was treated by the administration of sorafenib, a multiple kinase inhibitor.A patient, female ag...

Background: Fine-needle aspiration biopsy is the ‘gold standard’ in the preoperative management of thyroid nodules.Aim: The aim of this study was to investigate whether serum TSH is a predictor of thyroid malignancy in patients presenting with thyroid nodules.Subjects and methods: About 565 patients without overt thyroid dysfunction, who presented with palpable thyroid nodule(s) between 1988 and 2004 and underwent at leas...

Background: Growth Hormone (GH) and insulin-like growth factor 1 (IGF-1) are the biomarkers used to assess disease activity in acromegaly. Consensus guidelines from the Endocrine Society (2014) recommend a normal (age/sex-adjusted) IGF-1 in combination with a suppressed random GH<1 μg/l for biochemical remission. However, these results are discordant in some patients. The clinical significance of the IGF-1/GH dichotomy in the follow-up of these patients is unclear and...

Background: Acromegaly is characterised by growth hormone (GH) and insulin-like growth factor (IGF-1) hypersecretion. The disease is associated with increased cardiovascular, cerebrovascular and metabolic co-morbidities, resulting in excess mortality. A target GH <1 μg/l and normalised IGF-1 values correlate with mortality risk reduction. However, there is lack of consensus over which biomarker, GH or IGF-1, better predicts increased morbidity and/ or mortality.<p...

Introduction: Catecholamine excess causes profound vasoconstriction, resulting in reduced intravascular volume. Pheochromocytoma crisis can be further complicated with acute stress (Takotsubo-like) cardiomyopathy, attributed to the toxic catecholamine effect on the myocardium, and cardiogenic shock leading to tissue ischemia.Aim: To present a rare case of pheochromocytoma crisis, complicated with fulminant cardiogenic shock, which led to life-threatening...

IntroductionPrimary aldosteronism (PA) is associated with cardiovascular events and target organ damage, such as left ventricular (LV) hypertrophy and cardiac dysfunction. However the impact of subtle aldosterone secretion on cardiac function has not yet been evaluated.AimTo prospectively evaluate the cardiac function using echocardiographic indices in patients with biochemical overt, mild PA and essential hy...

IntroductionGlucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) are the two novel classes of anti-diabetic agents with compelling efficacy, in terms of glucose-lowering and cardio-renal protection. Euglycemic diabetic ketoacidosis (EDKA) is a serious rare adverse effect of SLT2i while the use of GLP-1RA has been scarcely linked with acute pancreatitis in humans.Case presentatio...

Introduction-Aim: Manifest dream content is rarely studied in dream research. Conflicting results have been presented regarding dream recall and affect vis-à-vis the menstrual cycle. Progestagens may improve dream recall. Thus, we aimed to assess dream recall/affect vis-à-vis the menstrual cycle in a large sample of women.Subjects-methods: We studied 779 women (mean age +S.D.: 31+9 years). The subjects were give...

Background and aim: The role of derangements of nitric oxide (NO) metabolism in the pathogenesis of complications of type 1 diabetes mellitus (T1D) is not sufficiently clear. There is little data on simultaneous measurements of NO metabolites nitrite and nitrate (NO2/NO3) in urine and serum in T1D. Data about the measurement of NO production by electronparamagnetic spectroscopy (EPR) in whole blood in T1D were never published. To fill this gap we have cha...